Systems Biotechnology
Connecting cellular metabolism and genome-scale models to understand culture performance.
We use genome-scale metabolic models and constraint-based analysis to study cellular pathways, nutrient requirements and production characteristics. Work on enzyme-capacity-constrained CHO-cell models, cell-line-specific polyamine metabolism and data-driven, model-guided media development connects biological understanding with bioprocess design.
WHY IT MATTERS
Understanding how cells use nutrients provides a biological basis for cell-line-specific media and culture strategies.
Research directions
- Genome-scale metabolic modeling
- Enzyme capacity and constraint-based analysis
- Cellular metabolism and media design