Bioprocess Digital Twins
Integrating process data, hybrid models and predictive simulation.
Yonsei UniversityBioprocess Engineering Laboratory
Engineering bioprocesses. From cells to systems.
Connecting cell culture, process analytics and digital twins. Advancing biomanufacturing through experiments and data.
Discover BPELBioprocess Research & Training
Research at a glance
Connecting research methods, biological products and bioprocess development.
Core technologies
Process Analytical Technology
Real-time sensing, analytics, soft sensors and process understanding.
Self-Driving Laboratories
Connecting automation, active learning and sequential experimentation.
CFD & Hydrodynamics
Spatial flow analysis, mixing, shear, mass transfer and scale-up.
AI-Driven Optimization
Machine learning, Bayesian optimization and model-guided design.
Systems Biotechnology
Genome-scale metabolic models and constraint-based analysis.
Biological products & applications
Recombinant Proteins
Therapeutic proteins and enzymes
Monoclonal Antibodies
Antibody-based biologics
AAV Vectors
Viral vectors for gene delivery
Cell & Gene Therapies
Manufacturing processes for cell and gene therapies
Artificial Blood
Oxygen carriers and blood substitutes
Cultivated Meat
Cell-based food bioprocesses
Bioprocess development
Cell Culture Media Development
Cell-line-specific formulations and AI-guided media optimization.
Transient Gene Expression Media & Process Development
TGE media, PEI–DNA transfection and transient protein production.
Fed-Batch Process Optimization
Feeding strategy, culture performance and product quality.
Continuous Bioprocess Development
Perfusion, cell retention and process intensification.
Bioreactor Design & Scale-up
Geometry, CFD-guided design, scale-up and process transfer.
Process Monitoring & Control
PAT-enabled analytics, monitoring and predictive control.
Selected publications
Selected work from our laboratory.
Join & collaborate
Bring your questions. Build what comes next.
Please introduce your research interests and relevant experience. Availability and project fit are discussed individually.
Join the laboratoryResearch enquiries